Building native IgG-like bispecific antibodies that enhance drug-like properties
Build native IgG-like bispecific antibodies
Phanes’ bispecific antibody technology platform is PACbody™ (PAC = Pairing of Alternative Cysteines), a proprietary approach for constructing bispecific antibodies that have native IgG-like structures with superb CMC characteristics. PACbodies can be designed to be fit for platform in the conventional manufacturing process for monoclonal antibodies.
PACbodyTM is a native IgG-like bispecific antibody platform with minimal structural change.
- Charged pairs can be used to enhance correct pairing if necessary.
- Charged pairs can be used to enable conventional fit-for-platform manufacturing process if necessary.
Build bispecific antibodies with modulated activities
A second technology platform Phanes is developing is ATACCbody™, which allows for construction of conjugated IgG-like bispecific antibodies (ATACCbodies) whose activities are modulated by the environment they are in. The technology is designed for targeting solid tumors using immuno-oncology molecules with minimal risk of cytokine release syndrome (CRS) seen in traditional immuno-oncology therapies.