SAN DIEGO, June 16, 2020 /PRNewswire/ — Phanes Therapeutics, Inc. (Phanes), an emerging leader in innovative discovery research in immuno-oncology announced today that it has developed a proprietary bispecific antibody technology platform, PACbody™, which enables construction of a bispecific antibody using any pair of monoclonal antibodies (mAbs) while maintaining the IgG-like structure. The technology was presented at the BIO Digital 2020.
”The beauty of the PACbody™ bispecific antibody platform is that it’s a ‘plug and play’ technology to quickly make an IgG-like bispecific antibody – the native structure of both arms of the bispecific antibody is maintained,” said Dr. Hui Zou, PhD, Chief Scientific Officer (CSO) of Phanes Therapeutics.
”Phanes is an emerging leader in innovative research in biologics aimed at targeting various cancers. In the last couple of years, we have built a differentiated pipeline. Now with the development of the PACbody™ bispecific antibody platform, we can advance multiple bispecific antibodies to target several types of solid tumors in a precise and selective manner and with more potent cancer cell killing mechanisms. We are very excited about having this technology, and we can expand its impact by partnering with pharma and biotech companies in its application in different disease areas,” said Ming Wang, PhD/MBA, CEO of Phanes Therapeutics, “At Phanes, our mission is to become a source of innovation in the biopharma industry and we are fully committed to delivering robust therapeutic molecules to patients. In addition, we’d like to leverage our PACbody™ technology to help advance the innovation of other players in the industry.”
Phanes built two out-licensing partnerships last year, including a licensing agreement with Hanmi Pharmaceutical Co., LTD (Hanmi) that allows Hanmi to evaluate and license antibody sequences against an undisclosed target from Phanes and use them in multiple projects, and a licensing agreement that allows Fosun Kite (a joint venture by Kite/Gilead and Fosun Pharma) to use a collection of high-affinity humanized antibodies and single-chain fragment variable (scFv) molecules targeting two novel cancer antigens for the development and commercialization of innovative CAR-T products for solid tumor treatments.
Phanes is a biotech company focused on discovery and development of innovative biologic drugs for tumors and eye diseases. Based at San Diego (USA), the company’s management team members previously held senior managerial and R&D positions in leading global pharmaceutical and biotech companies, with tremendous experience in R&D, business development and commercialization. For more information, please visit www.phanesthera.com.